Formulation of Film Coated Tablets of Norfloxacin and Tinidazole

The aim of the present study was development and optimization of an efficacious, pharmaco-economical, palatable and marketable film coated tablet formulation of Norfloxacin-Tinidazole. Bitter taste of both drugs reduces the patient compliance & hence marketability. However it has been shown that film coating technology economical & useful in masking the taste. The core tablets with maximum hardness & minimum disintegration time were selected for film coating. (F-1 & F-07) The optimized formulation F-07 showed hardness, friability, disintegration time and drug release in range 9 kg/cm2, 0.17 0.02%, 27.40 2.1 sec. & 100% release in 30 min. respectively. For all tablet formulation drug release at the end of 30 min was found in the range of 52.78 0.09 to 100.07 0.5 % and from the obtained results, F-07 was selected as an optimized formulation for designing palatable tablet. Therefore it can be concluded that the present work discusses in depth the development and optimization of an efficacious, pharmaco-economical, palatable and marketable tablet formulation of Norfloxacin and Tinidazole.

Author: Anilkumar Shinde, Harinath More
Publisher: LAP Lambert Academic Publishing
Published: 12/13/2018
Pages: 96
Binding Type: Paperback
Weight: 0.33lbs
Size: 9.00h x 6.00w x 0.23d
ISBN13: 9786139977369
ISBN10: 6139977363
BISAC Categories:
- Medical | Pharmacology

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