Simvastatin Solid Dispersion Prepared by Microwave Fusion Technique

Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion.

Author: Chaudhary Haresh, Patel B. N., Patel D. M.
Publisher: LAP Lambert Academic Publishing
Published: 02/13/2014
Pages: 124
Binding Type: Paperback
Weight: 0.42lbs
Size: 9.00h x 6.00w x 0.29d
ISBN13: 9783846504055
ISBN10: 384650405X
BISAC Categories:
- Medical | Pharmacology

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