Taste Mask Orodispersible Tablet of Metronidazole

Patients who have problems in swallowing encounter difficulties in taking tablets, particularly pediatric and geriatric patients. Such problems can be resolved by means of orodispersible tablets. These tablets disintegrate instantaneously when put on tongue, releasing the drug that dissolves or disperses in the saliva.Metronidazole is active against a wide variety of anaerobic protozoal parasites and anaerobic bacteria.The present study aim to prepare tablets that can rapidly disintegrate in oral cavity (orodispersible), another challenge with this model drug is to mask the bitter taste. Taste masking was achieved by using aminoalkyl methacrylate copolymer (Eudragit E-100) in the different ratio (1:2 and 1:3) by extrusion technique. The IR shows that there was no significant evidence for interaction between drug and polymers. Six formulations were prepared using taste masked granules and different disintegrants (LH-11) and Avicel PH-102 by varying concentration.

Author: Anupam Jain, Suresh Kumar Sahu, Aditya Nath Pandey
Publisher: LAP Lambert Academic Publishing
Published: 03/22/2012
Pages: 88
Binding Type: Paperback
Weight: 0.31lbs
Size: 9.00h x 6.00w x 0.21d
ISBN13: 9783848442973
ISBN10: 3848442973
BISAC Categories:
- Medical | Pharmacology

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