Description
This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.
Author: Yunjiao Zhang
Publisher: Springer
Published: 01/10/2023
Pages: 156
Binding Type: Paperback
Weight: 0.56lbs
Size: 9.21h x 6.14w x 0.37d
ISBN13: 9789811681684
ISBN10: 9811681686
BISAC Categories:
- Technology & Engineering | Nanotechnology & MEMS
- Technology & Engineering | Chemical & Biochemical
- Science | Life Sciences | Cell Biology