Description
Section 1: Diversity, Chemical biology and Ecology of Actinomycetes; and the Discovery of Natural Products
Chapter 1: An overview on Natural products from Actinomycetes: their discovery and biosynthesis.
Chapter 2: Isolation, identification (cultural and molecular techniques), and systematics of Actinomycetes from various sources (marine, soil, extremophilic environment).Chapter 3: Studies on diversity of nonribosomal peptide synthetase and polyketide synthase gene clusters among taxonomically close Actinomycetes strains.
Chapter 4: Chemical elicitors and signaling molecules and their role in elicitation of secondary metabolism in Actinomycetes.
Chapter 5: Regulation of antibiotic biosynthesis genes in Actinomycetes at molecular level.
Chapter 6: Screening strategies for inhibitors against cancer cells from natural Products repository of Actinomycetes.
Chapter 7: Rare and endophytic Actinomycetes in the biosynthesis of bioactive metabolites.
Chapter 8: Advances in bioactivity guided isolation of natural products from Actinomycetes.Chapter 9: Natural product discovery from non-Streptomyces Actinomycetes.
Chapter 10: Use of high-efficiency CRISPR/Cas9-mediated genome editing to study biology of Actinomycetes.
Section 2: Genomic approaches and synthetic biology tools in Actinomycetes drug discovery and industrial compounds
Chapter 11: An overview of biomedical, biotechnological and industrial applications of Actinomycetes
Chapter 12: Genomics and proteomics approach in natural product discovery in Actinomycetes.Chapter 13: Structural dereplication and strain dereplication strategies and metabolomics in natural product research.
Chapter 14: Genome mining of rare Actinomycetes and cryptic pathways for secondary metabolites.
Chapter 15: Glycosylated bioactive compound discovery by from Actinomycetes by combination of genome mining, gene inactivation and activation of silent biosynthetic clusters.
Chapter 16: Genetic engineering for overproducing bioactive secondary metabolites in Actinomycetes
Chapter 17: Transcriptional gene cluster refactoring for increased secondary metabolites production
Chapter 18: Synthetic biology in Actinomycetes for natural product discovery
Chapter 19: Metabolic engineering of antibiotic factories: new tools for antibiotic production in Actinomycetes
Chapter 20: Bioinformatic tools for use in pks and nrps discovery in Actinomycetes.
Author: Ravishankar V. Rai
Publisher: Springer
Published: 04/16/2022
Pages: 508
Binding Type: Hardcover
Weight: 1.99lbs
Size: 9.21h x 6.14w x 1.13d
ISBN13: 9789811661310
ISBN10: 9811661316
BISAC Categories:
- Science | Life Sciences | Microbiology
- Medical | Immunology
- Medical | Pharmacology
About the Author
Ravishankar V. Rai received his MSc (1980) and PhD (1989) from the University of Mysore, India. Currently, he is working in the Department of Studies in Microbiology, University of Mysore, Mysore. His current research and publications in food microbiology, microbial quorum sensing, microbial influenced corrosion and nanotechnology have been well received by the international scientific committee. He edited books with reputed publishers such as CRC Press and Wiley publications. Prof. Rai has received awards from UNESCO Biotechnology Action Council Programme (Visiting Fellow, 1996), UGC Indo-Israel Culture Exchange Programme (1998), DBT Overseas Fellowship (2008), Indo-Hungarian Educational Exchange Programme Fellowship (2011) and INSA - bilateral exchange fellowship (2015), Incoming Fellowship (2017) from Cardiff University in the UK, and invitation from Mauritius Research Council, Mauritius (2018), to conduct collaborative research with renowned scientists from international universities. He visited Massey University, New Zealand, under Eric Ojala fund International Travel Fellowship in 2019.
Jamuna A. Bai is working as an Assistant Professor in JSS Academy of Higher Education & Research, Mysore. She has completed MSc and PhD in Microbiology from University of Mysore, India. She pursued her PhD under the guidance of Dr. Ravishankar Rai V. Her doctoral research was funded by NMPB, Govt of India and Indian Council of Medical Research. As an ICMR Senior Research Fellow and for her doctoral research, she carried out studies on food safety, role of quorum sensing and biofilms in food-related bacteria and developed phytochemical based quorum-sensing inhibitors and anti-biofilm agents. She completed her post doctoral research in UGC sponsored University with Potential Excellence Project on synthesis and biological application of functionalized nanoparticles from University of Mysore. Her research work included application of functionalized nanomaterials and peptides as antimicrobials, biofilm inhibitors and anti-cancer agents. She has authored 30 research articles, reviews and book chapters and co-edited 6 books for CRC Press, USA . She has received grants and awards from IAFP, USA and ICFMH to present her research findings at international conferences. She has been awarded the Interstellar Initiative Early Career Investigator Funding jointly by the Japan Agency for Medical Research and Development (AMED) and the New York Academy of Sciences (NYAS) in 2021.
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